查看狗狗血管肉瘤的手术与多柔比星治疗的源代码


原文：https://pubmed.ncbi.nlm.nih.gov/8947871/

发表于：1996

== 摘要 ==

在一项前瞻性研究中，使用了 46 只经组织学证实的除皮肤以外的不同部位血管肉瘤的狗，以确定辅助阿霉素（30 mg/m2，静脉注射，每 3 周，5 次治疗）在肿瘤部分或完全切除后 10 至 14 天的疗效。数据分析包括假设影响治疗反应、无病间隔 （DFI） 或生存时间 （ST） 的变量信息。收集的其他信息包括年龄、性别、品种、体重、既往治疗、手术类型、原发肿瘤位置、转移的存在、阿霉素的剂量数、对阿霉素治疗的反应（完全或部分反应）以及以下组织学标准：总体分化、核多形性、坏死百分比、有丝分裂评分、组织学总分和分级。手术结果（完全手术切除与不完全手术切除）显着影响生存时间（P < .001）。20% 的无病狗在 1 岁时存活，而手术后有残留肿瘤的狗在 1 年时都没有存活。大多数组织学标准（核多形性、有丝分裂评分、分级、总体分化）对于完全切除肿瘤的狗，具有显著的 （P < .05） 或接近显著的与 ST 的独立关联。DFI 的分析结果在完全切除肿瘤的狗中通常与 ST 相似。46 只狗中有 27 只 （58.7%） 成功切除了肿瘤的所有临床证据。手术结果（切除所有可见肿瘤的能力）的Logistic回归分析表明，受试者的年龄是显着影响手术结果的唯一因素（P = .017）。随着年龄的增长，成功的可能性增加。那些以前接受过血管肉瘤治疗的狗往往 （P = .08） 具有较短的 DFI 和 ST。因此，完全去除所有肿瘤证据，然后服用 5 剂阿霉素可能是患有血管肉瘤的狗的有效治疗方法。成功切除所有肿瘤的狗的平均 ST 和中位 ST 分别为 267 天和 172 天。肿瘤切除不完全的狗的平均 ST 和中位 ST 分别为 172 天和 60 天。同样，预后变量（例如完全切除所有肿瘤证据的能力、组织学标准和患者年龄）是预测结果的潜在重要预后变量。

Forty-six dogs with histologically confirmed hemangiosarcoma of various locations other than skin were used in a prospective study to determine the efficacy of adjuvant doxorubicin (30 mg/m2 IV q 3 weeks for 5 treatments) 10 to 14 days after the tumor was partially or completely excised. Analysis of the data included information on variables that were hypothesized to influence response to therapy, disease-free interval (DFI), or survival time (ST). Other information collected included age, gender, breed, weight, prior therapy, type of surgery, location of the primary tumor, presence of metastases, number of doses of doxorubicin, response to doxorubicin therapy (complete or partial response), and the following histological criteria: overall differentiation, nuclear pleomorphism, percent necrosis, mitotic score, total histological score, and grade. Surgery outcome (complete versus incomplete surgical excision) markedly influenced survival times (P < .001). Twenty percent of the dogs rendered free of disease were alive at 1 year, whereas none of the dogs that had residual tumor after surgery were alive at 1 year. Most of the histological criteria (nuclear pleomorphism, mitotic score, grade, overall differentiation) had marked (P < .05), or close to marked, independent associations with ST for dogs that had complete tumor removal. Results from analysis of DFI were generally similar to those of ST in dogs with complete excision of the tumor. Twenty-seven of the 46 dogs (58.7%) had all clinical evidence of tumour successfully removed. Logistic regression analysis of surgical outcome (ability to remove all visible tumor) suggested that age of the subject was the only factor markedly influencing surgical outcome (P = .017). As age increased, the probability of success increased. Those dogs that had previous treatment for their hemangiosarcoma tended (P = .08) to have a shorter DFI and ST. Therefore, complete removal of all evidence of tumor followed by 5 doses of doxorubicin may be an effective treatment for dogs with hemangiosarcoma. Dogs that had all tumor successfully removed had a mean and median ST of 267 and 172 days, respectively. Dogs with incomplete tumor removal had a mean and median ST of 172 and 60 days, respectively. Similarly, prognostic variables such as the ability to completely excise all evidence of tumor, histological criteria, and age of the patient are potentially important prognostic variables for predicting outcome.

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