查看BBB的源代码

== 摘要 ==

血液循环和神经组织之间的界面具有独特的特性，这些特性被术语“血脑屏障”（BBB） 所包含。该屏障的主要功能，即维持大脑稳态、调节内流和外排运输以及防止伤害，都由其特殊的多细胞结构决定。每种组成细胞类型对 BBB 的完整性都做出了不可或缺的贡献。但是，如果 BBB 的一个成员失败，导致屏障崩溃，可能会产生严重的后果，并可能发生神经炎症和神经退行性变。在这篇评论中，我们重点介绍了最近获得的关于 BBB 开发和维护的机械见解。然后，我们讨论了 BBB 破坏如何导致或促进神经系统疾病。最后，我们研究了如何利用这些知识来探索 BBB 修复的新可能性。

The interface between the blood circulation and the neural tissue features unique characteristics which are embraced by the term ‘blood-brain barrier’ (BBB). The main functions of this barrier, namely maintenance of brain homeostasis, regulation of influx and efflux transport, and protection from harm, are determined by its specialized multicellular structure. Every constituent cell type makes an indispensible contribution to the BBB’s integrity. But, if one member of the BBB fails and as a result, the barrier breaks down, there can be dramatic consequences, and neuroinflammation and neurodegeneration can occur. In this Review we highlight recently gained mechanistic insights into the development and maintenance of the BBB. We then discuss how BBB disruption can cause or contribute to neurological disease. Finally, we examine how this knowledge can be used to explore new possibilities for BBB repair.

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