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=== 治疗 (Treatment) ===

'''DOX 方案 (DOX protocol)'''

在DOX治疗组中，总共对64只狗施用了232剂DOX。每只狗的平均DOX剂量为4（中位数为4;范围为1-9）。九只狗接受了超过 5 剂的 DOX，最大剂量为 9 剂。58 只 （91%） 狗以 30 mg/m^2 剂量治疗，6 只狗 （9%） 以 1 mg/kg 剂量治疗。56 只狗 （88%） 每 2 周接受治疗一次，6 只狗 （9%） 每 3 周接受治疗;没有 2 只狗的治疗时间表信息。

A total of 232 doses of DOX were administered to 64 dogs in the DOX-treated group. The mean number of DOX doses per dog was 4 (median, 4; range, 1–9). Nine dogs received more than 5 doses of DOX and the maximum number of doses administered was 9. Fifty-eight (91%) dogs were treated at the 30 mg m−2 dose and 6 dogs (9%) were treated at 1 mg kg−1. Fifty-six dogs (88%) received treatment every 2 weeks and six dogs (9%) were treated every 3 weeks; treatment schedule information was not available for 2 dogs.


'''响应者的并发和后续协议 (Concurrent and subsequent protocols for responders)'''

11 只狗 （17%） 开始同时进行节拍化疗，包括环磷酰胺（12.5-15 mg/m^2 PO q/24）和非甾体抗炎药在 DOX 方案的前三个周期的某个时间点。14 只狗 （22%） 在完成 DOX 方案或至少四个 DOX 周期后接受节拍化疗。一只狗在完成 DOX 治疗后每周接受长春新碱（0.5 mg/m^2 IV）和标准剂量环磷酰胺（250 mg/m^2 PO，分 3 天）维持治疗。

Eleven dogs (17%) began concurrent metronomic chemotherapy, consisting of cyclophosphamide (12.5–15 mg/m^2 PO q per 24) and a non-steroidal anti-inflammatory drug at some point during the first three cycles of DOX protocol. Fourteen dogs (22%) were treated with metronomic chemotherapy after the completion of their DOX protocols or following at least four cycles of DOX. One dog underwent maintenance treatment with vincristine (0.5 mg m−2 IV), and standard dose cyclophosphamide (250 mg m−2 PO divided over 3 days) given on a weekly basis upon completion of treatment with DOX.


'''救援协议 (Rescue protocols)'''

23 只狗 （36%） 在 DOX 化疗失败后接受了抢救方案治疗。使用的抢救方案包括长春新碱/环磷酰胺 （n=14）、节律化疗 （n=2）、长春碱/环磷酰胺 （n=3）、长春新碱 （n=2） 和卡铂 （n=1）。一只狗接受了另一种剂量的 DOX 治疗，因为在初始 DOX 方案完成 90 天后，狗在接受节拍化疗时发生了复发。

Twenty-three dogs (36%) were treated with a rescue protocol after failing DOX chemotherapy. Rescue protocols used included vincristine/ cyclophosphamide (n=14), metronomic chemotherapy (n=2), vinblastine/cyclophosphamide (n=3), vincristine (n=2) and carboplatin (n=1). One dog was treated with another dose of DOX, as relapse occurred while the dog was being treated with metronomic chemotherapy 90 days after the completion of the initial DOX protocol.


'''其他治疗 (Other treatments)'''

DOX治疗组中的三只狗（5%）接受了其他病变的手术治疗，包括两只接受脾切除术的狗和一只接受肝叶切除术的狗。

Three dogs (5%) in the DOX-treated group underwent surgical treatment for additional lesions, including two dogs that underwent splenectomy and one dog that underwent a liver lobectomy.

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