查看基于多柔比星的化疗对右心房肿块和心包积液狗的回顾性评估的源代码
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基于多柔比星的化疗对右心房肿块和心包积液狗的回顾性评估
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== Introduction == 狗心包积液 (PE) 最常见的原因是肿瘤或特发性疾病(Kersetetter 等人,1997 年,Dunning 等人,1998 年,Ware & Hopper 1999 年,Stafford Johnson 等人,2004 年,Weisse 等人,2005 年,MacDonald 等人,2009 年,Rajagopalan 等人,2013 年)。右心房和心脏底部是 PE 狗发现肿瘤的两个最常见位置。当发现源自右心房的肿块时,血管肉瘤 (HSA) 是迄今为止最常见的组织病理学诊断,尽管偶尔会发现其他肿瘤,包括神经内分泌肿瘤、甲状腺腺癌、间皮瘤和淋巴瘤(Ware & Hopper 1999, MacDonald et al. 2009, Rajagopalan et al. 2013)。虽然心包穿刺术可以缓解体征,但 PE 经常在存在右心房 (RA) 肿块的情况下迅速复发,并且长期预后较差,大多数狗在诊断后 30 天内死亡或被安乐死(Kersetetter 等人,1997 年,Dunning 等人,1998 年,Stafford Johnson 等人,2004 年,Weisse 等人,2005 年,MacDonald 等人,2009 年)。因此,已经评估了进一步的治疗方案,包括心包切除术(Kersetetter 等人,1997 年)和手术切除 RA 肿块,联合或不联合辅助化疗(Weisse 等人,2005 年)。与单独手术相比,手术切除 RA 肿块后给予基于多柔比星的化疗显着缩短了生存时间(Weisse 等人,2005 年)。然而,手术通常昂贵、侵入性强,并且经常与并发症有关(Weisse 等人,2005 年)。因此,本研究旨在评估基于多柔比星的化疗作为超声心动图检查中发现 RA 肿块和 PE 的狗的唯一治疗方法。 The most common cause of pericardial effusion (PE) in dogs is neoplasia or idiopathic disease (Kersetetter et al. 1997, Dunning et al. 1998, Ware & Hopper 1999, Stafford Johnson et al. 2004, Weisse et al. 2005, MacDonald et al. 2009, Rajagopalan et al. 2013). The right atrium and the heart base are the two most common locations where neoplasia is identified in dogs with PE. When a mass is identified originating from the right atrium, haemangiosarcoma (HSA) is by far the most common histopathological diagnosis although other neoplasms are occasionally identified including neuroendocrine tumours, thyroid gland adenocarcinoma, mesothelioma and lymphoma (Ware & Hopper 1999, MacDonald et al. 2009, Rajagopalan et al. 2013). While pericardiocentesis can relieve the signs, PE frequently rapidly recurs in the presence of a right atrial (RA) mass and the long-term prognosis is poor with most dogs dying or being euthanased within 30 days of diagnosis (Kersetetter et al. 1997, Dunning et al. 1998, Stafford Johnson et al. 2004, Weisse et al. 2005, MacDonald et al. 2009). Consequently, further treatment options have been evaluated including pericardiectomy (Kersetetter et al. 1997) and surgical resection of the RA mass with or without adjuvant chemotherapy (Weisse et al. 2005). The administration of doxorubicin-based chemotherapy after surgical resection of the RA mass significantly improved survival time compared with surgery alone (Weisse et al. 2005). However, surgery is typically expensive, invasive and frequently associated with complications (Weisse et al. 2005). As such, this study was designed to evaluate the administration of doxorubicin-based chemotherapy as the only treatment for dogs identified with a RA mass and PE on echocardiographic examination. <br>
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