查看犬血管肉瘤化疗管理 – 更新的源代码

== 化疗 (Chemotherapy) ==

多柔比星（阿霉素）是血管肉瘤中常用的化疗药物，既可以作为单一药物使用[13,14]，也可以与其他药物（如环磷酰胺[15]和达卡巴嗪[16]联合使用。阿霉素也被用作与环磷酰胺和长春新碱的三药联合化疗，用于治疗狗血管肉瘤[17]。U'任等[18]评价了针对犬血管肉瘤的同种异体肿瘤裂解物疫苗的安全性和有效性。研究发现，使用多柔比星对接受化疗的狗进行疫苗接种会产生强烈的体液免疫反应，平均生存期为 182 天。将免疫疗法与化疗相结合可以提高患有血管肉瘤的犬患者的平均生存期。

Doxorubicin is the chemotherapeutic agent used commonly in case of hemangiosarcoma both as a single agent [13,14] and as a combination therapy with other agents like cyclophosphamide [15] dacarbazine [16]. Doxorubicin is also used as a three-drug combination chemotherapy with cyclophosphamide and vincristine in managing hemangiosarcoma in dogs [17]. U’ren et al. [18] evaluated the safety and efficacy of allogeneic tumor lysate vaccine directed against hemangiosarcomas in canines. It was found that vaccinating the dogs undergoing chemotherapy using doxorubicin produced strong humoral immune response and had mean survival period of 182 days. Combining Immunotherapy with chemotherapy can improves the mean survival period of canine patients affected with hemangiosarcoma.


在体外评估时，发现用作水溶性纳米颗粒胶束制剂的药物紫杉醇对犬血管肉瘤细胞系有效。对血管肉瘤的作用是由于药物的凋亡启动活性[19]。研究推荐的50%抑制浓度在临床上是可以达到的。需要进一步的体内研究来评估紫杉醇对血管肉瘤的疗效。

The drug paclitaxel used as water-soluble nanoparticle micellar formulation was found to be effective against canine hemangiosarcoma cell lines when evaluated in-vitro. The action against hemangiosarcoma was due to the apoptosis initiating activity of the drug [19]. The 50% inhibitory concentration recommended by the study was found to be clinically achievable. Further in-vivo studies are required to evaluate the efficacy of paclitaxel against hemangiosarcoma.


白藜芦醇是一种天然存在的非黄酮类多酚化合物，被发现对两种血管肉瘤细胞系具有生长抑制作用，因此使其成为纳入用于治疗犬血管肉瘤的基于多柔比星的化疗方案的合适候选者。白藜芦醇与多柔比星的组合增加了多柔比星的细胞毒性作用，而没有增加其心脏毒性作用[20]。

Resveratrol, a naturally found non-flavonoid polyphenolic compound was found to be having growth-inhibitory effect on two hemangiosarcoma cell lines thus making it a suitable candidate for incorporating into doxorubicin based chemotherapeutic regimens used to manage hemangiosarcoma in canines. The combination of resveratrol with doxorubicin increased the cytotoxic effect of doxorubicin without increasing its cardio toxic effects [20].

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