查看犬血管肉瘤的治疗：2000 年及以后的源代码

== 传统疗法 (Traditional Therapy) ==

从历史上看，手术一直是 HSA 的首选治疗方法，尽管它对改善总体生存时间几乎没有作用[4,18,19] 三项对仅通过手术治疗的脾脏 HSA 狗的研究报告称，中位生存时间为 2-3 个月[4,18,19]。心脏 HSA 的手术切除也产生了不令人满意的结果，中位生存时间从 3 到 5 个月不等[20-22]。皮肤 HSA 通常与更长的生存时间有关[23]。由于手术的局限性[11]，据报道，基于多柔比星的各种方案，无论是否添加长春新碱和环磷酰胺，都具有最佳生存时间[2,3,24-27]。已发表的方案包括单药阿霉素（30 mg/m^2，静脉注射，每 3 周一次，最多 5 个周期）；多柔比星和环磷酰胺（阿霉素作为单药方案，在每 3 周周期的第 3-6 天静脉注射环磷酰胺 50-75 mg/m^2）；和长春新碱、多柔比星和环磷酰胺（多柔比星作为单药方案，环磷酰胺在每 3 周周期的第 1 天静脉注射 100 mg/m^2，长春新碱在每个周期的第 8 天和第 15 天静脉注射）[1-3,24-26]。据报道，各种基于多柔比星的方案的生存时间从 140 到 202 天不等， 虽然没有任何一个方案明显更好。

Historically, surgery has been the treatment of choice for HSA, although it does little to improve overall survival times.4,18,19 Three studies of dogs with splenic HSA treated by surgery alone reported median survival times of 2–3 months.4,18,19 Surgical excision for cardiac HSA also yields unsatisfactory results, with median survival times ranging from 3 to 5 months.20–22 Cutaneous HSA is generally associated with longer survival times.23 Because of the limitations of surgery, chemotherapy has evolved into a principal component of therapy.11 Various protocols based on doxorubicin with and without the addition of vincristine and cyclophosphamide have been reported to have the best survival times.2,3,24–27 Published protocols include single-agent doxorubicin (30 mg/m2 intravenously every 3 weeks for up to 5 cycles); doxorubicin and cyclophosphamide (doxorubicin as for single-agent protocol, with cyclophosphamide incorporated at 50–75 mg/m2 intravenously on days 3–6 of every 3-week cycle); and vincristine, doxorubicin, and cyclophosphamide (doxorubicin as for single-agent protocol, with cyclophosphamide incorporated at 100 mg/m2 intravenously on day 1 of every 3-week cycle, and vincristine at 0.75 mg/m2 intravenously on days 8 and 15 of each cycle).1–3,24–26 Survival times ranging from 140 to 202 days have been reported for the various doxorubicin-based protocols, although no protocol is clearly superior [3,24-27].


'''NOTES:'''
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Protocol 1:
单药阿霉素（30 mg/m^2，静脉注射，每 3 周一次，最多 5 个周期）
Single-agent doxorubicin (30 mg/m^2 intravenously every 3 weeks for up to 5 cycles)

Protocol 2:
多柔比星和环磷酰胺（阿霉素作为单药方案，在每 3 周周期的第 3-6 天静脉注射环磷酰胺 50-75 mg/m^2）
doxorubicin and cyclophosphamide (doxorubicin as for single-agent protocol, with cyclophosphamide incorporated at 50–75 mg/m^2
 intravenously on days 3–6 of every 3-week cycle)

Protocol 3:
长春新碱、多柔比星和环磷酰胺 联用（多柔比星作为单药方案，环磷酰胺在每 3 周周期的第 1 天静脉注射 100 mg/m^2，长春新碱在每个周期的第 8 天和第 15 天静脉注射）
vincristine, doxorubicin, and cyclophosphamide (doxorubicin as for single-agent protocol, with cyclophosphamide incorporated at 100 mg/m^2
 intravenously on day 1 of every 3-week cycle, and vincristine at 0.75 mg/m2 intravenously on days 8 and 15 of each cycle)
</source>

24kg 的 狗的体表面积约 0.84 m^2: [https://www.msdvetmanual.com/multimedia/table/weight-to-body-surface-area-conversion-for-dogs MSD Veterinary Manual]

[https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jvim.15440 使用计算机断层扫描和放射治疗计划软件开发计算狗体表面积的新公式][https://pubmed.ncbi.nlm.nih.gov/30835925/ 2]：
[[文件:BSA-new.png]]


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