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== The GABA system and addiction ==

GABA 系统和成瘾

* GABA is the major inhibitory neurotransmitter in the brain.
* GABA binds with GABA-a and GABA-b receptors to inhibit neuronal activity.
* Substances of abuse can downregulate or upregulate the GABA system.
* GABA-b receptors modulate substance reward and reinforcement behaviours.
* Disturbances to the GABA system may pre-date substance addiction.
* Compounds that target the GABA system may help in the  treatment of addiction

 • GABA 是大脑中主要的抑制性神经递质。
 • GABA 与 GABA-a 和 GABA-b 受体结合以抑制神经元活动。
 • 滥用物质可以下调或上调 GABA 系统。
 • GABA-b 受体调节物质奖励和强化行为。
 • 对 GABA 系统的干扰可能早于物质成瘾。
 • 靶向 GABA 系统的化合物可能有助于治疗成瘾

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