查看Ch75 Dermatological Pharmacology的源代码

==== Eflornithine (依氟鸟氨酸) ====

Eflornithine is an inhibitor of ornithine decarboxylase (ODC) that is approved for the reduction of excessive and unwanted facial hair in women. ODC is the rate-limiting enzyme in the synthesis of polyamines, which are important in cellular migration, differentiation, and proliferation. Levels of ODC activity are higher in proliferating cells, such as in follicular matrix cells in anagen phase, and inhibiting ODC decreases hair growth. Eflornithine 13.9% cream is applied twice daily and is intended to be used along with the patient’s preferred hair removal method to slow hair regrowth.

依氟鸟氨酸是鸟氨酸脱羧酶 （ODC） 的抑制剂，被批准用于减少女性过多和不需要的面部毛发。ODC 是多胺合成中的限速酶，在细胞迁移、分化和增殖中很重要。在增殖细胞中，例如在生长期的滤泡基质细胞中，ODC 活性水平较高，抑制 ODC 会减慢毛发生长。依氟鸟氨酸 13.9% 乳膏每天使用两次，旨在与患者首选的脱毛方法一起使用，以减缓毛发再生。

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