查看犬血管肉瘤的治疗：2000 年及以后的源代码

== 抗转移药物 (Antimetastatic Agents) ==

转移性“级联”是一个逐步的过程，肿瘤细胞通过该过程生长并扩散到身体的其他部位（图1）。简而言之，级联反应的阶段包括转化、血管生成、运动和侵袭、栓塞和进入循环、在毛细血管床中停留、粘附毛细血管壁、外渗到器官实质、适应局部微环境、肿瘤细胞增殖，然后进一步血管生成。了解转移所涉及的过程，可以生产和使用旨在控制转移级联反应中特定步骤的药物。

下一节将讨论几种能够通过影响血管生成（干扰素、沙利度胺）、预防基质分解（基质金属蛋白酶抑制剂、米诺环素）和饮食调整来改变转移的药物。下面讨论的许多药物已经或正在接受犬 HSA 治疗的检查。


The metastatic ‘‘cascade’’ is a step-wise process by which neoplastic cells grow and spread to other locations in the body (Fig 1). Briefly, the stages of the cascade include transformation, angiogenesis, motility and invasion, embolism and entrance into circulation, lodgment in capillary beds, adherence to capillary walls, extravasation into organ parenchyma, adjustment to local microenvironment, tumor cell proliferation, and then further angiogenesis. An understanding of the processes involved in metastasis allows for the production and use of agents designed to control specific steps within the metastatic cascade.

The following section will discuss several agents capable of altering metastasis through effects on angiogenesis (interferon, thalidomide), prevention of matrix breakdown (matrix metalloproteinase inhibitors, minocycline), and dietary modifications. Many of the agents discussed below have either been or are in the process of being examined for treatment of canine HSA.

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