查看狗狗原发性心脏血管肉瘤的流行病学、临床和病理特征：51例的回顾的源代码

=== 治疗和生存时间 (Treatment and survival time) ===

对于所有51只狗，使用Aronsohn [1]和Russell等人[25]的改良TNM世界卫生组织（WHO）分期方案进行临床分期。该系统基于肿瘤大小、浸润程度、淋巴结受累和远处转移体征，适用于犬HSA[14]。根据初次就诊时胸部X线摄影和腹部超声检查显示是否存在转移性疾病，31只没有远处转移证据的狗被归类为2期HAS，20只被归类为3期HSA（表1）。诊断时没有患有 1 期 HSA 的狗。

For all 51 dogs, clinical staging was performed using the modified TNM World Health Organization (WHO) staging protocol of Aronsohn [1] and Russell et al. [25]. This system is based on tumor size, degree of invasion, lymph node involvement and signs of distant metastasis and is applicable to canine HSA [14]. On the basis of the presence or absence of metastatic disease demonstrated by thoracic radiography and abdominal ultrasonography at initial presentation, 31 dogs that did not have evidence of distant metastasis were classified as having stage-2 HAS, and 20 were classified as having stage-3 HSA (Table 1). There were no dogs with stage-1 HSA at the time of diagnosis.


根据治疗方法，将 51 只狗分配到 4 组中的 1 组（表1）：

* A 组 - 不治疗（8 只：第 2、2 阶段;第 3、6 阶段）
* B 组 - 药物治疗（26：第2、12阶段;第3、14阶段）
* C 组 - 心包切除术和肿瘤切除术（12：2、12 期）
* D 组 - 心包切除术、肿瘤切除术和化疗（5：2、5期）


对 B 组的 26 只狗进行了医疗治疗，治疗方案包括给予各种抗生素，糖皮质激素，利尿剂，洋地黄和抗心律失常药物。26 只狗中有 9 只也接受了间歇性心包穿刺术，2 只狗 3 次，4 只狗 2 次，3 只狗 1 次。

C 组所有 12 只狗均接受了心包次全切除术和 RAu 或 RA 肿块的手术切除术（图 1）。

D组的五只狗均接受了心包次全切除术、RAu 或 RA 肿块手术切除术和辅助化疗。

对于 C 组和 D 组，对 10 只狗进行了右侧开胸术，对 7 只狗进行了正中胸骨切开术。


The 51 dogs were allotted to 1 of 4 groups based on methods of treatment: no treatment − group A (8: stage 2, 2; stage 3, 6); medical treatment − group B (26: stage 2, 12; stage 3, 14); pericardectomy and tumor resection − group C (12: stage 2, 12); and pericardectomy, tumor resection and chemotherapy − group D (5: stage 2, 5) (Table 1). Medical management was attempted in 26 dogs of group B. Treatment regimens included administration of various antibiotics, glucocorticoids, diuretics, digitalis and antiarrhythmic drugs. Nine of the 26 dogs were also treated with intermittent pericardiocentesis, 3 times in 2 dogs, twice in 4 and once in 3. All 12 dogs in group C underwent subtotal pericardectomy and surgical resection of the RAu or RA mass (Fig. 1). Five dogs in group D all underwent subtotal pericardectomy, surgical resection of the RAu or RA mass and adjuvant chemotherapy. For groups C and D, a right lateral thoracotomy was performed in 10 dogs, and a median sternotomy was performed in 7.

[[文件:Cardiac.HSA.Fig1.png | 900px]]


选择的化疗策略为3周周期，第1日使用阿霉素（30mg/m^2，IV）和环磷酰胺（100mg/m^2，IV），第 8 天和第 15 天使用长春新碱（0.5mg/m2，IV）[7]。'''该方案在拆线时启动'''，每 21 天重复一次，最多 5 个周期或直到疾病进展。'''每周进行一次体格检查、全血细胞计数和血清生化分析，以发现不良反应'''。

生存时间定义为从临床诊断之日到死亡的时间。

The chemotherapy strategy chosen was 3-week cycles consisting of doxorubicin (30 mg/m^2, IV) and cyclophosphamide (100 mg/m^2, IV) on day 1 and vincristine (0.5 mg/m2, IV) on days 8 and 15 [7]. The protocol was initiated at the time of suture removal and repeated every 21 days for a maximum of 5 cycles or until disease progression. A physical examination and a CBC and serum biochemical analysis were performed weekly to detect adverse reactions.

Survival time was defined as the time from the date of clinical diagnosis to death.

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