查看2014.Doxorubicin.HSA的源代码

=== 治疗剂量和时间表 (Treatment dosing and schedule) ===

接受治疗的狗接受单药化疗方案，包括 DOX（狗 1 mg/kg <10 kg，狗 30 mg/m^2 >10 kg），每 2-3 周静脉输注一次。狗继续接受治疗，直到检测到疾病进展或完成计划的方案，通常包括至少五次总治疗。如果主治临床医生认为合适，狗可以接受超出计划方案的额外剂量的 DOX。一组未接受化疗的当代狗（提交给同一机构）被用作 CTL 人群。接受DOX的狗的主人被提供口服抗恶心药物（maropitant，2mg/kg PO，每天一次），以备不时之需。

Dogs undergoing treatment received a single-agent chemotherapy protocol consisting of DOX (1 mg/kg for dogs <10 kg, 30 mg/m^2 for dogs >10 kg) given once every 2–3 weeks by intravenous infusion. Dogs continued to receive treatments until disease progression was detected or the planned protocol, typically consisting of a minimum of five total treatments, was completed. Dogs could receive additional doses of DOX beyond the planned protocol if deemed appropriate by the attending clinician. A contemporary group of dogs (presented to the same institution) not undergoing chemotherapy was used as a CTL population. Owners of dogs receiving DOX were provided oral anti-nausea medication (maropitant, 2 mg kg−1 PO once daily) for use as needed.

<br>