查看Ch75 Dermatological Pharmacology的源代码

==== Bimatoprost (比马前列素) ====

Bimatoprost is a prostaglandin analogue approved for topical treatment of hypotrichosis of the eyelashes by increasing their growth, including length, thickness, and darkness. The prostaglandin-mediated increase in eyelash growth was serendipitously noted during the use of intraocular prostaglandin analogues for glaucoma. The proposed mechanism of eyelash growth is by an increase in the fraction of hairs in, and the duration of, the anagen phase. Increased pigmentation of the hairs is thought to occur due to stimulation of melanin production without an increase in the number of melanocytes. Importantly, brown pigmentation of the iris and eyelid skin may occur, and the increased iris pigmentation may be permanent.

比马前列素是一种前列腺素类似物，被批准用于局部治疗睫毛少毛症，通过增加睫毛的生长，包括长度、厚度和深色。在使用眼内前列腺素类似物治疗青光眼期间，偶然注意到前列腺素介导的睫毛生长增加。提出的睫毛生长机制是通过增加生长期中的毛发比例和持续时间。毛发色素沉着增加被认为是由于刺激黑色素生成而没有增加黑色素细胞数量的。重要的是，虹膜和眼睑皮肤可能会出现棕色色素沉着，并且虹膜色素沉着增加可能是永久性的。

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