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=== Naftifine (萘替芬) ===

Naftifine is a synthetic allylamine that inhibits squalene-2,3-epoxidase, a key enzyme in the fungal biosynthesis of ergosterol. The drug has broad-spectrum fungicidal activity in vitro. Naftifine hydrochloride is available as a 1% cream or gel. It is effective for the topical treatment of tinea cruris and tinea corporis; twice-daily application is recommended. The drug is well tolerated, although local irritation in 3% of treated patients and allergic contact dermatitis have been reported. Naftifine also may be efficacious for cutaneous candidiasis and tinea versicolor, although the drug is not approved for these uses.

Naftifine (萘替芬) 是一种合成的烯丙胺，可抑制角鲨烯-2,3-'''环氧化物酶'''，角鲨烯-2,3-环氧化物酶是''麦角固醇''真菌生物合成中的关键酶。该药物在体外具有广谱杀真菌活性。盐酸萘替芬有 1% 乳膏或凝胶形式。它对股癣和体癣的局部治疗有效；建议每天使用两次。该药物耐受性良好，尽管已报道 3% 的接受治疗的患者出现局部刺激和过敏性接触性皮炎。萘替芬也可能对皮肤念珠菌病和花斑癣有效，尽管该药物未被批准用于这些用途。

<b style=color:#0cf>【注】</b>烯丙胺类抗真菌药物原理为：其抑制真菌<b style='color:#f80'>角鲨烯环氧化酶</b>，从而减少<b style='color:#f80'>麦角固醇</b>（<b style='color:#0b0'>真菌细胞膜重要成分，其与磷脂结合增加膜的稳定性，缺乏则膜会破损</b>）的生物合成。

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