查看犬血管肉瘤的治疗：2000 年及以后的源代码

== 四环素衍生物 (Tetracycline Derivatives) ==

米诺环素是四环素的半合成衍生物，具有抗血管生成和基质金属蛋白酶抑制特性，已成为多项人类癌症研究的焦点。米诺环素似乎抑制局部胶原酶活性，从而阻止血管生成。这种机制是由于基质金属蛋白酶的抑制还是通过基质金属蛋白酶非依赖性机制尚不清楚[72] 米诺环素在涉及人类患者颅内胶质瘤和实验室动物胰岛细胞癌和刘易斯肺癌的研究中是有效的[73-75] 一项研究显示，患有 HSA 的狗单独接受化疗（AC 方案）或化疗和米诺环素，并未显示生存时间的显着差异[76] 然而，米诺环素可能对病情较轻的狗有益[76]。

Minocycline, a semisynthetic derivative of tetracycline that has both antiangiogenic and matrix metalloproteinase inhibitory properties, has become the focus of several human cancer studies. Minocycline seems to inhibit local collagenase activity, thereby preventing angiogenesis. Whether this mechanism is due to inhibition of matrix metalloproteinases or via a matrix metalloproteinase–independent mechanism is unknown.72 Minocycline has been efficacious in studies involving intracranial glioma in human patients and islet cell carcinoma and Lewis lung carcinoma in laboratory animals.73–75 One study in which dogs with HSA received either chemotherapy (AC protocol) alone or chemotherapy and minocycline did not demonstrate a significant difference in survival times.76 However, minocycline may provide benefit in dogs with less advanced disease[76]

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