Pharmacology

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蓝皮圣经第 14 版 (2022) 精要
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药理学蓝皮圣经第 14 版 (2022) 精要
  
Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, 14th Edition
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[[文件:Pharmacology.cover.jpg | 469px]]
  
== Ch61 Antifungal Agents ==
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* Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, 14th Edition (November 1, 2022)
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* Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, 13th Edition (December 5, 2017),有中文影印版,湖南科学技术出版社,2022 出版
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* Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, 12th Edition(January 10, 2011),有中文翻译版,人民卫生出版社,2017 出版
  
抗真菌剂
 
  
=== Terbinafine ===
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英文原版更新周期为 5 年左右,和大部分经典专业教材更新习惯一致。
  
特比萘芬
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<br>
  
特比萘芬是一种合成烯丙胺,在结构上类似于外用剂萘替芬(见下面的讨论)。它抑制真菌角鲨烯环氧化酶,从而减少麦角甾醇的生物合成。
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== 精要 ==
  
Terbinafine is a synthetic allylamine, structurally similar to the topical agent naftifine (see discussion that follows). It inhibits fungal squalene epoxidase and thereby reduces ergosterol biosynthesis.
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[[Ch32 Treatment of Hypertension]] 高血压的治疗
  
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[[Ch36 Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs]] 凝血和抗凝剂、纤溶剂和抗血小板药物
  
ADME:特比萘芬吸收良好,但由于肝脏中的首过代谢,生物利用度约为 40%。该药物在皮肤、指甲和脂肪中积累。初始 t1/2 约为 12 小时,但在稳态下延长至 200 至 400 小时。不推荐将特比萘芬用于明显氮质血症或肝功能衰竭的患者。利福平降低,西咪替丁增加血浆特比萘芬浓度。
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[[Ch45 Hematopoietic Agents: Growth Factors, Minerals, and Vitamins]] 造血剂:生长因子、矿物质和维生素
  
ADME: Terbinafine is well absorbed, but bioavailability is about 40% due to first-pass metabolism in the liver. The drug accumulates in skin, nails, and fat. The initial t1/2 is about 12 h but extends to 200 to 400 h at steady state. Terbinafine is not recommended in patients with marked azotemia or hepatic failure. Rifampin decreases and cimetidine increases plasma terbinafine concentrations.
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[[Ch61 Antifungal Agents]]  抗真菌剂
  
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[[Ch75 Dermatological Pharmacology]] 皮肤病药理学
  
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<br>
  
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== Reference ==
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* [[Pharmacology]]
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* [[Physiology]]
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* [[Addiction]]
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* [[BBB]] [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080800/ 血脑屏障概述]
  
 
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2024年11月22日 (五) 10:36的最后版本

药理学蓝皮圣经第 14 版 (2022) 精要

Pharmacology.cover.jpg

  • Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, 14th Edition (November 1, 2022)
  • Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, 13th Edition (December 5, 2017),有中文影印版,湖南科学技术出版社,2022 出版
  • Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, 12th Edition(January 10, 2011),有中文翻译版,人民卫生出版社,2017 出版


英文原版更新周期为 5 年左右,和大部分经典专业教材更新习惯一致。


[编辑] 1 精要

Ch32 Treatment of Hypertension 高血压的治疗

Ch36 Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs 凝血和抗凝剂、纤溶剂和抗血小板药物

Ch45 Hematopoietic Agents: Growth Factors, Minerals, and Vitamins 造血剂:生长因子、矿物质和维生素

Ch61 Antifungal Agents 抗真菌剂

Ch75 Dermatological Pharmacology 皮肤病药理学


[编辑] 2 Reference


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