Pharmacology

2024年11月22日 (五) 10:36的最后版本

药理学蓝皮圣经第 14 版 (2022) 精要

Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, 14th Edition (November 1, 2022)
Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, 13th Edition (December 5, 2017)，有中文影印版，湖南科学技术出版社，2022 出版
Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, 12th Edition(January 10, 2011)，有中文翻译版，人民卫生出版社，2017 出版

英文原版更新周期为 5 年左右，和大部分经典专业教材更新习惯一致。

[编辑] 1 精要

Ch32 Treatment of Hypertension 高血压的治疗

Ch36 Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs 凝血和抗凝剂、纤溶剂和抗血小板药物

Ch45 Hematopoietic Agents: Growth Factors, Minerals, and Vitamins 造血剂：生长因子、矿物质和维生素

Ch61 Antifungal Agents 抗真菌剂

Ch75 Dermatological Pharmacology 皮肤病药理学

@@ 第1行： / 第1行： @@
-蓝皮圣经第 14 版 (2022) 精要
+药理学蓝皮圣经第 14 版 (2022) 精要
-Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, 14th Edition
+[[文件:Pharmacology.cover.jpg | 469px]]
-== Ch61 Antifungal Agents ==
+* Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, 14th Edition (November 1, 2022)
+* Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, 13th Edition (December 5, 2017)，有中文影印版，湖南科学技术出版社，2022 出版
+* Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, 12th Edition(January 10, 2011)，有中文翻译版，人民卫生出版社，2017 出版
-抗真菌剂
-=== 特比萘芬 (Terbinafine) ===
+英文原版更新周期为 5 年左右，和大部分经典专业教材更新习惯一致。
-Terbinafine is a synthetic allylamine, structurally similar to the topical agent naftifine (see discussion that follows). It inhibits fungal squalene epoxidase and thereby reduces ergosterol biosynthesis.
+<br>
-特比萘芬是一种合成烯丙胺，在结构上类似于外用剂萘替芬（见下面的讨论）。它抑制真菌角鲨烯环氧化酶，从而减少麦角甾醇的生物合成。
+== 精要 ==
+[[Ch32 Treatment of Hypertension]] 高血压的治疗
-'''ADME''': Terbinafine is well absorbed, but bioavailability is about 40% due to first-pass metabolism in the liver. The drug accumulates in skin, nails, and fat. The initial t1/2 is about 12 h but extends to 200 to 400 h at steady state. Terbinafine is not recommended in patients with marked azotemia or hepatic failure. Rifampin decreases and cimetidine increases plasma terbinafine concentrations.
+[[Ch36 Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs]] 凝血和抗凝剂、纤溶剂和抗血小板药物
-'''ADME'''：特比萘芬吸收良好，但由于肝脏中的首过代谢，生物利用度约为 40%。该药物在皮肤、指甲和脂肪中积累。初始 t1/2 约为 12 小时，但在稳态下延长至 200 至 400 小时。不推荐将特比萘芬用于明显氮质血症或肝功能衰竭的患者。利福平降低血浆特比萘芬浓度，西咪替丁增加血浆特比萘芬浓度。
+[[Ch45 Hematopoietic Agents: Growth Factors, Minerals, and Vitamins]] 造血剂：生长因子、矿物质和维生素
+[[Ch61 Antifungal Agents]]  抗真菌剂
-'''Therapeutic Uses''': Terbinafine, given as one 250-mg tablet daily for adults, is somewhat more effective than itraconazole for nail onychomycosis. Duration of treatment varies with the site of infection but typically ranges between 6 and 12 weeks. The efficacy for the treatment of onychomycosis can be improved by the simultaneous use of amorolfine 5% nail lacquer (amorolfine is not approved for use in the U.S.). Terbinafine is also effective for the treatment of tinea capitis and has been used for the off-label treatment of ringworm elsewhere on the body.
+[[Ch75 Dermatological Pharmacology]] 皮肤病药理学
-'''治疗用途'''： 特比萘芬，成人每天一片 250 毫克片剂，比伊曲康唑对指甲甲真菌病更有效。治疗持续时间因感染部位而异，但通常在 6 至 12 周之间。同时使用 5% 阿莫罗芬指甲油可以提高治疗甲癣的疗效（阿莫罗芬在美国未获批使用）。特比萘芬对治疗头癣也有效，并已用于身体其他部位的癣的超说明书治疗。
+<br>
+== Reference ==
-'''Adverse Effects''': The drug is well tolerated, with a low incidence of GI distress, headache, or rash. Very rarely, fatal hepatotoxicity, severe neutropenia, Stevens-Johnson syndrome, or toxic epidermal necrolysis may occur. Systemic terbinafine therapy for onychomycosis should be postponed until after pregnancy is complete.
+* [[Pharmacology]]
+* [[Physiology]]
-'''不良反应'''：该药物耐受性良好，胃肠道不适、头痛或皮疹的发生率较低。极少数情况下，可能会发生致命的肝毒性、严重的中性粒细胞减少、Stevens-Johnson 综合征或中毒性表皮坏死松解症。甲癣的全身性特比萘芬治疗应推迟到妊娠完成后。
+* [[Addiction]]
+* [[BBB]] [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080800/ 血脑屏障概述]
 <br>

Pharmacology

2024年11月22日 (五) 10:36的最后版本

[编辑] 1 精要

[编辑] 2 Reference

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