脂质体包封的胞壁酰三肽磷脂酰乙醇胺辅助免疫治疗狗脾血管肉瘤:一项随机多机构临床试验
来自Jack's Lab
原文:https://pubmed.ncbi.nlm.nih.gov/9815908/
全文:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241611/
Published: 1995
1 Notes
BY BH1RBH
米伐木肽(Mifamurtide),又称为利米洛肽(Liposomal muramyl tripeptide phosphatidylethanolamine,LMTP-PE),是一种用于治疗非转移性骨肉瘤(non-metastatic osteosarcoma)的药物。它是一款肽类药物,通过激活人体免疫系统,增强免疫细胞对恶性肿瘤的攻击能力,从而提高治疗效果。米伐木肽 (mifamurtide) 的参考价:规格为 4mg,价格为 15480 元一盒。来源
胞壁酰三肽磷脂酰乙醇胺(muramyl tripeptide phosphatidyl ethanolamine,MTP-PE)是胞壁酰二肽(muramyl dipeptide,MDP)合成的亲脂性衍生物,它是革兰氏阳性和革兰氏阴性细菌细胞壁中最小的天然免疫刺激成分[5-7]。与MDP一样,MTP-PE具有激活单核-巨噬细胞特性[7];然而,MTP-PE亲脂性更强,MTP-PE在体外具有更强的免疫刺激作用[8]。MTP-PE还具有更长的血浆半衰期。寿命比MDP更长[9]。 来源
2 Abstract
3 Reference
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- 2010: 狗的胸腔镜次全心包切除术和右心房肿块切除术 Thoracoscopic subtotal pericardiectomy and right atrial mass resection in a dog
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- 2014: 基于多柔比星的化疗对右心房肿块和心包积液狗的回顾性评估 A retrospective evaluation of doxorubicin-based chemotherapy for dogs with right atrial masses and pericardial effusion
- 2017: 多柔比星-环磷酰胺与多柔比星-达卡巴嗪辅助治疗犬血管肉瘤的比较 Comparison of doxorubicin-cyclophosphamide with doxorubicin-dacarbazine for HSA
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