静脉注射脂质体包封的胞壁酰三肽治疗狗骨肉瘤
原文：https://pubmed.ncbi.nlm.nih.gov/2733037/
Published: 1989
1 Abstract
犬骨肉瘤 (osteosarcoma) 是狗的一种自发性恶性肿瘤，其特征是在诊断时微转移至肺和肺外组织。标准治疗包括截肢，但中位生存时间为 3-4 个月，因转移而死亡。进行了一项随机双盲试验，以评估脂质体封装的胞壁酰三肽-磷脂酰乙醇胺（脂质体/MTP-PE）作为治疗因骨肉瘤而截肢的狗的转移。14 只狗接受脂质体/MTP-PE 治疗，13 只狗接受空脂质体治疗。用脂质体/MTP-PE 治疗的狗的中位生存时间为 222 天，而用空脂质体治疗的狗的中位生存时间为 77 天（P 小于 0.002）。在脂质体/MTP-PE治疗组中，仍有四只狗在手术后 1 年以上存活且无转移。治疗耐受性良好。除了注射后 2-6 小时体温轻度升高（1-2 摄氏度）外，没有观察到显着的毒性作用。
Canine osteosarcoma is a spontaneous malignancy in dogs, characterized by micrometastasis to pulmonary and extrapulmonary tissues at the time of diagnosis. Standard treatment involves amputation of the affected leg, but median survival time is 3-4 months with death due to metastasis. A randomized double-blind trial was conducted to evaluate liposome-encapsulated muramyl tripeptide-phosphatidylethanolamine (liposome/MTP-PE) as a treatment for metastasis in dogs undergoing amputation for osteosarcoma. Fourteen dogs were treated with liposome/MTP-PE, and 13 were treated with empty liposomes. Median survival time was 222 days for dogs treated with liposome/MTP-PE, compared to 77 days for dogs treated with empty liposomes (P less than .002). In the liposome/MTP-PE-treated group there were still four dogs alive and free of metastasis at greater than 1 year post surgery. Treatment was well tolerated; no significant toxic effects were noted except for mild elevations in body temperature (1-2 degrees C) for 2-6 hours post injection.
2 Introduction
3 Reference
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